Hindi maaaring isagawa ang radiation theraphy sa bahaging ito dahil sa interior curvature ng spinal cord. Ang mataas na dose ng radiation ay magreresulta ng grabeng erossive gastritis.
Ang radiation theraphy sa upper third ng esophagus naman ang paraan para magamot ang cancer. Ang operasyon sa bahaging ito ay mahirap gawin. Mas mababa ang naiuugnay na mortality sa paraan ng radiation kaysa sa operasyon. Although distant metastasis are a contra indication to radical radiotheraphy, extra-esophageal invasion may still be encomppassed within the radical high dose zone. Treatment is given daily over four to six weeks. Pre-operative and post-operative radiation therapy does not prolong survival, and has not clearly defined rules in the management of this disease.
Ang dysphagia at regurtitation ang mga symptoms ng esopahageal cancer. Ang mga sintomas na nabanggit ay distressing. A short course on radiotherapy will relieve dysphagia and most patients with acceptable short term morbidity and can usually be repeated if necessary.