CHICAGO (AP) — Harold Ramis, the bespectacled "Ghostbusters" sidekick to Bill Murray whose early grounding in live comedy led to blockbuster movies such as "National Lampoon's Animal House," ''Caddyshack" and "Groundhog Day," died Monday. He was 69.
Ramis, who suffered for several years from an autoimmune disease that caused inflammation and damage to his blood vessels, died at his home in the Chicago suburbs, surrounded by family and friends, his talent agency said.
The writer-director-actor quietly and often off-screen created an unparalleled and hugely influential body of laughs in a filmography that includes some of the most beloved and widely quoted comedy classics of the last 30 years.
His death rattled a modern comedy world Ramis helped build. His legacy as a father figure to generations of comedians was appropriately captured in Judd Apatow's "Knocked Up," in which Ramis was cast as Seth Rogen's father, he said, "because we all saw him as the dream dad."
"Harold Ramis made almost every movie which made me want to become a comedy director," Apatow said. "These films are the touchstones of our lives."
Chevy Chase, whom Ramis directed in "Caddyshack" and "National Lampoon's Vacation," called him "a great man who shunned unnecessary Hollywood-type publicity."
"It was Harold who acted out and gave me the inspiration for the character of Clark Griswold" in the National Lampoon Vacation movies, Chase said Monday. "I was really copying Harold's impression of Clark."
Admittedly lacking the dashing leading-man looks of some of his peers, Ramis was memorably nebbishy: curly haired, gangly and bespectacled. He played Ghostbuster scientist Egon Spengler (naturally, the one with all the ideas), and Bill Murray's Army recruit buddy in "Stripes."
But Ramis, a Chicago native and early member of the improv comedy troupe Second City, was a far larger force behind the camera. He co-wrote and directed "Caddyshack," ''Groundhog Day," and "Analyze This." He also helped pen "Meatballs," ''Stripes" and "Ghostbusters."
Ramis could reasonably be credited with making more people roll in the aisles from the late '70s to the early '90s than almost anyone else. Murray, Ramis' frequent collaborator, said in a statement: "He earned his place on this planet."
With a Baby Boomer antiestablishment bent, Ramis — who escaped Vietnam War service, he claimed, by checking every box on the medical-history form — pushed against institutions: the college dean of "Animal House," the country club members of "Caddyshack," the drill sergeant of "Stripes."
He was known to have a spiritual pull, on full display in the wry but earnest existentialism of "Groundhog Day" (1993), in which Murray re-lives a day until he finally gets it right. His "Ghostbusters" co-star and Second City mate Dan Aykroyd said: "May he now get the answers he was always seeking."
The son of Chicago shopkeepers, Ramis was born Nov. 21, 1944, in Chicago. After graduating from Washington University in St. Louis, he briefly worked in a mental institution. He often said, seriously, that the experience helped prepare him for working with actors.
Ramis would help recalibrate the epicenter of American comedy at Second City, which he joined in 1969. He was soon followed by many of his later collaborators: John Belushi ("Animal House"), Murray and Aykroyd. In 1976, he became head writer for the Canadian-based comedy show "Second City Television," or "SCTV."
Chicago, he later said in the book of interviews "And Here's the Kicker," conditioned him to living "slightly on the outside of the mainstream."
"New York and L.A. were the real centers of culture in America, and we were kind of a sideshow," said Ramis. "There's always more comedy in being alienated than in fitting in."
He soon moved on to bigger projects — the legendary 1978 comedy "National Lampoon's Animal House." With Murray as the comic lead, the Second City alums paired up for numerous projects: 1979's "Meatballs," 1980's "Caddyshack" and 1981's "Stripes."
Perhaps the most well-known of their collaborations was "Ghostbusters," which became one of the biggest hits of the 1980s. Ramis helped write the 1984 movie, in which he stars as the commonsense member of a group of parapsychologists who try to catch ghosts.
"The best comedy touches something that's timeless and universal in people," Ramis told The Associated Press in a 2009 story about the 50th anniversary of Second City. "When you hit it right, those things last."
His last hit was "Analyze This," the therapist-meets-mobster comedy starring Billy Crystal and Robert DeNiro. Some of his last efforts (2000's "Bedazzled," 2009's "Year One") were notable flops. A third "Ghostbusters" has long been rumored, but has yet to materialize in any substantial way.
Ramis is survived by his wife, Erica; sons Julian and Daniel; daughter Violet; and two grandchildren.